Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments : Potential applications
Identifieur interne : 001682 ( Main/Exploration ); précédent : 001681; suivant : 001683Preparation of nanoparticles by the self-organization of polymers consisting of hydrophobic and hydrophilic segments : Potential applications
Auteurs : Takami Akagi [Japon] ; Masanori Baba [Japon] ; Mitsuru Akashi [Japon]Source :
- Polymer : (Guildford) [ 0032-3861 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Biodégradabilité.
English descriptors
- KwdEn :
Abstract
This review describes the preparation of core-corona type polymeric nanoparticles and their applications in various technological and biomedical fields. Over the past two decades, we have studied the synthesis and clinical applications of core-corona polymeric nanoparticles composed of hydrophobic polystyrene and hydrophilic macromonomers. These nanoparticles were utilized as catalyst carriers, carriers for oral peptide delivery, virus capture agents, and vaccine carriers, and so on. Moreover, based on this research, we attempted to develop novel biodegradable nanoparticles composed of hydrophobic poly(y-glutamic acid) (y-PGA) derivatives (γ-hPGA). Various model proteins were efficiently entrapped on/into the nanoparticles under different conditions: encapsulation, covalent immobilization, and physical adsorption. The encapsulation method showed the most promising results for protein loading. It is expected that biodegradable γ-hPGA nanoparticles can encapsulate and immobilize various biomacromolecules. Nanoparticles consisting of hydrophobic and hydrophilic segments have great potential as multifunctional carriers for pharmaceutical and biomedical applications, such as drug, protein, peptide or DNA delivery systems.
Affiliations:
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uniqKey="Akagi T" first="Takami" last="Akagi">Takami Akagi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Applied Chemistry, Graduate School of Engineering, Osaka University</s1><s2>2-1 Yamadaoka, Suita, 565-0871</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>2-1 Yamadaoka, Suita, 565-0871</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi Center Building</s1><s2>4-1-8 Honcho, Kawaguchi, 332-0012</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>4-1-8 Honcho, Kawaguchi, 332-0012</wicri:noRegion></affiliation></author><author><name sortKey="Baba, Masanori" sort="Baba, Masanori" uniqKey="Baba M" first="Masanori" last="Baba">Masanori Baba</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi Center Building</s1><s2>4-1-8 Honcho, Kawaguchi, 332-0012</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>4-1-8 Honcho, Kawaguchi, 332-0012</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University</s1><s2>8-35-1 Sakuragaoka, Kagoshima 890-8544</s2><s3>JPN</s3><sZ>2 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>8-35-1 Sakuragaoka, Kagoshima 890-8544</wicri:noRegion></affiliation></author><author><name sortKey="Akashi, Mitsuru" sort="Akashi, Mitsuru" uniqKey="Akashi M" first="Mitsuru" last="Akashi">Mitsuru Akashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Applied Chemistry, Graduate School of Engineering, Osaka University</s1><s2>2-1 Yamadaoka, Suita, 565-0871</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>2-1 Yamadaoka, Suita, 565-0871</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi Center Building</s1><s2>4-1-8 Honcho, Kawaguchi, 332-0012</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>4-1-8 Honcho, Kawaguchi, 332-0012</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Polymer : (Guildford)</title><title level="j" type="abbreviated">Polymer : (Guildf.)</title><idno type="ISSN">0032-3861</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Polymer : (Guildford)</title><title level="j" type="abbreviated">Polymer : (Guildf.)</title><idno type="ISSN">0032-3861</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphiphilic polymer</term><term>Biodegradability</term><term>Control release polymer</term><term>Drug carrier</term><term>Immobilized enzyme</term><term>Nanoparticle</term><term>Preparation</term><term>Protein</term><term>Review</term><term>Support</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Nanoparticule</term><term>Polymère amphiphile</term><term>Polymère vecteur</term><term>Vecteur médicament</term><term>Support</term><term>Protéine</term><term>Enzyme immobilisée</term><term>Préparation</term><term>Biodégradabilité</term><term>Article synthèse</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biodégradabilité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This review describes the preparation of core-corona type polymeric nanoparticles and their applications in various technological and biomedical fields. Over the past two decades, we have studied the synthesis and clinical applications of core-corona polymeric nanoparticles composed of hydrophobic polystyrene and hydrophilic macromonomers. These nanoparticles were utilized as catalyst carriers, carriers for oral peptide delivery, virus capture agents, and vaccine carriers, and so on. Moreover, based on this research, we attempted to develop novel biodegradable nanoparticles composed of hydrophobic poly(y-glutamic acid) (y-PGA) derivatives (γ-hPGA). Various model proteins were efficiently entrapped on/into the nanoparticles under different conditions: encapsulation, covalent immobilization, and physical adsorption. The encapsulation method showed the most promising results for protein loading. It is expected that biodegradable γ-hPGA nanoparticles can encapsulate and immobilize various biomacromolecules. Nanoparticles consisting of hydrophobic and hydrophilic segments have great potential as multifunctional carriers for pharmaceutical and biomedical applications, such as drug, protein, peptide or DNA delivery systems.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Akagi, Takami" sort="Akagi, Takami" uniqKey="Akagi T" first="Takami" last="Akagi">Takami Akagi</name></noRegion><name sortKey="Akagi, Takami" sort="Akagi, Takami" uniqKey="Akagi T" first="Takami" last="Akagi">Takami Akagi</name><name sortKey="Akashi, Mitsuru" sort="Akashi, Mitsuru" uniqKey="Akashi M" first="Mitsuru" last="Akashi">Mitsuru Akashi</name><name sortKey="Akashi, Mitsuru" sort="Akashi, Mitsuru" uniqKey="Akashi M" first="Mitsuru" last="Akashi">Mitsuru Akashi</name><name sortKey="Baba, Masanori" sort="Baba, Masanori" uniqKey="Baba M" first="Masanori" last="Baba">Masanori Baba</name><name sortKey="Baba, Masanori" sort="Baba, Masanori" uniqKey="Baba M" first="Masanori" last="Baba">Masanori Baba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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